THE
Diabetes
DAILYNEWS© CONCEPTUAL INDEX
for
[To View Headlines
without Links Click Here]
Control is good
and less expensive....
"Intensive blood glucose control in
patients with type 2 diabetes
significantly increased treatment costs but substantially
reduced the cost of complications and increased the
time free of complications"BMJ
[2000]320:1373-1378
"The diabetes attributable risk for
dementia of 8.8% suggests that diabetes may contribute to
the clinical syndrome in a substantial proportion of all
dementia patients.....";
Glycemic control is subject to
intervention. Better control may decrease hospitalization
among people with diabetes.
Thus, there is considerable potential for reducing health
care costs.........";
"Poor diabetic perioperative glycemic control is a
risk factor for infectious
complications...........";
"Stress Worsens Diabetic Control and Treatment of
Depression Improves Diabetic Control............";
"Jacuzzis may *help control [type 2]
diabetes*..........";
"ADA recommends admission of all diabetics
who are badly out of control.....";
Obesity, Leptin, K-ATP Channels
and Type 2 Diabetes....
"Fasting plasma IL-6
concentrations are positively related to
adiposity and negatively related to insulin action (Obesity Research [2001] 9:414-417
)
"Type 2 diabetes can
be delayed by changes in the lifestyles of high-risk
subjects." (N Engl J Med
[2001] 344:1343-50
"Big Whoop of the Year'
Award goes to those weenie-wonks who had to knock-out
brain insulin receptors to figure out that insulin is THE
PRANDIAL MESSAGE" (Science
[2000] 289: 2122-2125)";
"Obesity continues to increase rapidly in
the United States. To alter this trend, strategies and
programs for weight maintenance as well as weight
reduction must become a higher public health priority:-The prevalence of obesity
(defined as a body mass index >30 kg/m2) increased
from 12.0% in 1991 to 17.9%
in 1998. A steady increase was observed in all states; in
both sexes; across age groups, races, educational levels;
and occurred regardless of smoking status. The greatest
magnitude of increase was found in the following groups:
18- to 29-year-olds (7.1% to 12.1%), those with some
college education (10.6% to 17.8%), and those of Hispanic
ethnicity (11.6% to 20.8%). The magnitude of the
increased prevalence varied by region (ranging from 31.9%
for mid Atlantic to 67.2% for South Atlantic, the area
with the greatest increases) and by state (ranging from
11.3% for Delaware to 101.8% for Georgia, the state with
the greatest increases).....";
"Central abdominal fat is inversely and
independently related to insulin sensitivity after
adjusting for total fat in women in the early
postmenopausal period. Efforts to reduce either
subcutaneous abdominal fat or intraabdominal fat should
be helpful in reducing the risk of noninsulin-dependent
diabetes mellitus in postmenopausal women....."
|
Hypothesis
#NDC1.00 -
Obesity + beta-cell defect => Type 2 Diabetes
Obesity - beta-cell
defect => Morbid Obesity
- Hypothesis
#NDC1.01 -
- The
SUR-1/Kir6.2 complex is the Leptin
Receptor [CONFIRMED]
Hypothesis #NDC1.02 -
- Obesity
=> leptin => decreased
insulin secretion + increased
insulin resistance => IGT
- Hypothesis
#NDC1.03 -
IGT + beta-cell defect
=> Type 2 Diabetes
|
Obesity => Type 2 Diabetes
"How are obesity and Type 2 diabetes
related?...........";
"Hopkins Study Shows Overweight Young Males are at
Risk for the Development of Type 2
Diabetes...............";
"Data suggest that greater physical
activity level is associated with substantial reduction
in risk of type 2 diabetes, including physical activity
of moderate intensity and duration. JAMA.
1999;282:1433-1439.....";
"BMI correlates with increased all-cause mortality
in non-smoking Caucasian Americans (but not in
non-smoking black Americans)..........";
"Peroxisome ProliferatorActivated
Receptor gamma Gene Locus Is Related to Body Mass Index
and Lipid Values in Healthy Nonobese Subjects
.....";
Obesity => IL-6+TNF-alpha
=>Leptin
"Fasting plasma IL-6
concentrations are positively related to
adiposity and negatively related to insulin action (Obesity Research [2001] 9:414-417
)
"Local [adipocyte]
expression of TNF and plasma IL-6 are higher
in subjects with obesity-related insulin resistance.(Am J Physiol -Endo/Metab [2001] 280:
E745-E751)"
"Tumor Necrosis Factor (TNF) impairs insulin signaling through Insulin Receptor Substrate-1 (IRS-1) by activation
of a PhosphatidylInositol-3 kinase (PI-3k)/ Serine and threonine
kinase c-Akt (cloned from directly transforming murine
retrovirus AKT8, isolated from an AKR
mouse Thymoma
cell line) also known as Rac-alpha
-Related to the A and C kinases - or protein
kinase B-alpha (Akt)/mammalian Target Of
Rapamycin (mTOR) pathway, which is antagonized
by [3' phospholipid-] Phosphatase and Tensin Homologue Deleted from Chromosome ten
(PTEN/MUTATED
IN MULTIPLE ADVANCED CANCERS
1-MMAC1)".....(Proc. Natl. Acad. Sci. USA, [2001] 10.1073/pnas.051042298)
"Is leptin the link between obesity and
insulin resistance?.....";
"Leptin Levels Increase in Proportion to
the Extent of Obesity.....";
Obesity => Leptin =>
Decreased Insulin Secretion via Opening K-ATP Channels
"Targeted Overactivity of
beta- Cell KATP Channels Induces Profound
Neonatal Diabetes (Cell
[2000]:100,534-654).....";
"Expression of the functional leptin
receptor mRNA is found in pancreatic islets and directly
inhibits insulin secretion.....";
"The agouti gene product stimulates
pancreatic beta-cell Ca2+ signaling and insulin release..........";
"Leptin suppresses insulin secretion by the
activation of ATP-sensitive K+ channels in pancreatic
beta-cells.....";
"Leptin binds to VMH Kir6.2/SUR1
receptors ";
"Leptin rapidly suppresses insulin release
from insulinoma cells, rat and human islets and, in vivo,
in mice.....";
"Insulin occludes leptin activation of
ATP-sensitive K+ channels in rat CRI-G1 insulin secreting
cells";
"The Homeodomain of PDX-1 Mediates
Multiple Protein-Protein Interactions in the Formation of
a Transcriptional Activation Complex on the Insulin
Promoter.....";;
Sulfonylureas - which
prototypically close
K-ATP channels - may also increase Leptin
"Sulfonylurea therapy is associated with
increases in [insulin and] leptin levels despite weight
loss.....";
"Dexamethasone stimulates leptin release
from human adipocytes: unexpected inhibition by insulin.....";Obesity => Leptin =>
"U-shaped" Insulin Resistance Curve
Obesity => Leptin=>Downregulated PPAR-gamma=>Enhanced
Lipolysis and Decreased Lipogenesis
"Short-term adenovirus-induced
hyperleptinemia depletes adipocyte fat while profoundly
down-regulating lipogenic enzymes and their transcription
factor, peroxisome proliferator-activated receptor
(PPAR)gamma in epididymal fat; enzymes of fatty acid
oxidation and their transcription factor, PPARalpha,
normally low in adipocytes, are up-regulated, as are
uncoupling proteins 1 and 2. This transformation of
adipocytes from cells that store triglycerides to fatty
acid-oxidizing cells is accompanied by loss of the
adipocyte markers, adipocyte fatty acid-binding protein
2, tumor necrosis factor alpha, and leptin, and by the
appearance of the preadipocyte marker Pref-1....."
"Leptin administration to cultured rodent
hepatocytes increased gluconeogenesis, decreased
glycogenolysis, and decreased free fatty acid synthesis.
Nevertheless, CNS injection of leptin in the same species
improved measures of insulin tolerance....."(Rossetti L: Leptin regulation of hepatic
glucose metabolism [Concurrent session: Leptin regulation
of fuel metabolism]. 59th Annual Scientific
Sessions of ADA, San Diego, CA, 1999);
"Plasma Leptin Associated with
Insulin-Resistant Hypertension............";
"Leptin inhibits glycogen synthesis in the
isolated soleus muscle of obese (ob/ob) mice.....";
"Low levels of leptin seem to reverse
diabetes in mouse model of congenital lipodystrophy...........";
"Leptin appears to have a
U-shaped effect on insulin resistance and
is more active in visceral fat..................";
Obesity => Leptin =>
Decreases in (1) Agouti protein and (2) neuropeptide-Y
=>
=> Increases in (3) melanocortin function and (4)
satiety
"Hypothalamic agouti-related protein
messenger ribonucleic acid [and Neuropeptide-Y mRNA] are
inhibited by Leptin and stimulated by fasting.....";
"Agouti-related protein, an
endogenous antagonist of hypothalamic melanocortin
receptor, is intrically involved in leptin
action.....";
"Melanocyte Stimulating Hormone appears to
have appetite-suppressant activity.............";
"Leptin-associated
mutations cause down-regulation of prepro-orexin gene
expression.....";
|
Hypothesis
#NDC1.10 -
PPAR-gamma is the major
transcription factor for lipogenesis
- Hypothesis
#NDC1.11 -
Downregulation of PPAR-gamma by
leptin OVERRIDES upregulation by insulin
and is the major factor responsible for
post-prandial insulin resistance
|
Thiazolidinediones impact
Leptin, PPAR-gamma, and K-ATP Channels
"Dominant negative mutations in human
PPAR-gamma are associated with severe insulin resistance,
diabetes mellitus and hypertension.....";
"Diazoxide- and leptin-activated K(ATP)
currents show differential sensitivity to englitazone and
ciclazindol in rat CRI-G1 insulin-secreting cell lines....";
"Thiazolidinediones - which decrease
leptin message - appear to prevent
diabetes in the hyperleptinemic db/db
mouse................";
"A low calorie diet specifically down-regulates the
expression of PPAR gamma2 mRNA in adipose tissue of obese
humans
"Ciliary neurotrophic factor corrects
obesity [and hyperinsulinemia] associated with leptin
deficiency and resistance.....";
"An ascochlorin derivative, AS-6, reduces
insulin resistance in the genetically obese diabetic
mouse, db/db.....";
"Differential
effects of insulin-sensitizers troglitazone and
rosiglitazone on ion currents in rat vascular myocytes.....";
"Regulation
of glucose metabolism and opening of K(ATP) channels in
pancreatic beta-cells by NO.....";
"Interaction of vanadate with the cloned
beta cell K(ATP) channel.....";
Mitochondrial K-ATP Channels and
Cardiac Ischemia
"Diabetes or hyperglycemia
impairs activation of mitochondrial KATP channels during
infarction" (AJP - Heart Circ Physiol [2001] 280:
Issue 4, H1744-H1750)
"Opening of sarcolemmal KATPchannels
underlies ST elevation during ischemia" (Circulation Res. [2000] 87:837)
"Serum leptin is elevated in patients with
coronary artery disease"
"Either glyburide or
mitochondrial K(ATP) channel blocker 5-hydroxydecanoate
abolish cardioprotection by YM934 in a
concentration-dependent manner" J Pharmacol Exp Ther [1999] 291(2):710-716
"Results suggest that mitoK-atp
channels are downstream of PKC in the mechanism of
infarct-size limitation by A1-receptor
activation and that the anti-infarct tolerance afforded
by opening of mitoK-atp channels is
associated with preservation of mitochondrial function
during ischemia/reperfusion.....";
"Nitric Oxide (NO) directly activates
mitoK-atp channels and potentiates
the ability of diazoxide to open these channels. These
results provide novel mechanistic links between
NO-induced cardioprotection and mitoK-atp
channels.....";
"ATP-regulated
K+ channel in mitochondria:
pharmacology and function.....";
"Regulation
of mitochondrial KATP channel by redox agents.....";
"Rat
liver GTP-binding proteins mediate changes in
mitochondrial membrane potential and organelle fusion.....";
Mitochondrial Membranes , Mg++, Malate/Oxaloacetate
Translocators, Gluconeogenesis, and, Ketoacidosis....
|
Hypothesis #NDC2.00 - Gluconeogenic
Hormones affect Malate/Oxaloacetate Translocators
or Shuttles in
the mitochondrial membranes to result in (1)
Increased cytoplasmic
levels of OAA and
(2) Decreased mitochondrial
levels of malic acid.
- Hypothesis
#NDC2.01 -
Gluconeogenic hormones - particularly AVP
- directly inhibit Malic
Enzyme (malate
dehydrogenase) in both mitochondrial
matices and cytosol.
- Hypothesis
#NDC2.02 -
Insulin enhances
lipogenesis by increasing mitochondrial
membrane permeability to citrate
and over-riding inhibition of Malic
Enzyme
- Hypothesis
#NDC2.03 -
Lipolysis (FFA-CoA
ß-oxidation) results in increased
mitochondrial NADH(H+) to NAD+ ratios
thus further inhibiting the already
endergonic conversion of malate =>
oxaloacetate
- Hypothesis
#NDC2.04
- Malate/Oxaloacetate
Translocators (MOT) are dependent on
[Mg++]'s with lower levels resulting in
(1) Increased cytoplasmic
levels of OAA and (2) Decreased mitochondrial
levels of malic acid
|
"Type 2 Diabetes in whites, but not blacks, is
inversely associated with serum magnesium
levels................";
"Mg2+ control of respiration in isolated
rat liver mitochondria.....";
|
- Hypothesis
#NDC2.05
- Increased cytoplasmic
levels of OAA are gluconeogenic and
insulin-antagonistic
- Hypothesis
#NDC2.06
- Mitochondrial
levels of malic acid which are decreased
can result in
decreased mitochondrial respiration
|
"The role of malate in regulating the rate
of mitochondrial respiration in vitro.....";
"The role of malate in hormone-induced
enhancement of mitochondrial respiration.....";
"Sources of intramitochondrial malate.....";
"Pyruvate/malate antiporter in rat liver
mitochondria.....";
"Fumarate permeation in rat liver
mitochondria: fumarate/malate and fumarate/phosphate
translocators.....";
"Oxaloacetate permeation in rat kidney
mitochondria: pyruvate/oxaloacetate and malate/oxaloacetate
translocators.....";
"Oxaloacetate uptake into rat brain
mitochondria and reconstruction of the malate/oxaloacetate
shuttle.....";
"Capacity of the malate/oxaloacetate
shuttle for transfer of reducing
equivalents across the envelope of leaf chloroplasts.....";
"Aminooxyacetic acid inhibits the
malate-aspartate shuttle in isolated nerve terminals and
prevents the mitochondria from utilizing glycolytic
substrates.....";
"Suppression of the mitochondrial
oxidation of (-)-palmitylcarnitine by the
malate-aspartate and alpha-glycerophosphate shuttles.....";
"Dehydroepiandrosterone and related
steroids inhibit mitochondrial respiration in vitro.....";
"Regulation
of oxalacetate metabolism in liver mitochondria. Evidence
for nicotinamide adenine dinucleotide-malate
dehydrogenase equilibrium and the role of
phosphoenolpyruvate carboxykinase in the control of
oxalacetate metabolism in intact guinea pig and rat liver
mitochondria.....";
"Gluconeogenesis in vitro. Formation of
glucose 6-phosphate from malate by a cell-free rat-liver
system consisting of cytosol and mitochondria.....";
"Effect of alloxan on the transport of
dicarboxylate, tricarboxylate, pyruvate and glutamate in
isolated mouse liver mitochondria.....";
"Transport of malate and citrate into rat
brain mitochondria under hypoxia and anesthesia.....";
|
- Hypothesis
#NDC2.07
- Vasopressin is the
most potent gluconeogenic hormone in this
context and can -
in the absence of sufficient
insulin-induced compensation - virtually
abolish mitochondrial levels of OAA.
This results in inability to metabolize
Acetyl-CoA-SH and severe ketosis with
acidosis
- Hypothesis
#NDC2.08 - Dehydration
(through vomiting and/or diarrhea and/or
sweating and/or hypodipsia)
is the major
pathophysiologic cause of DKA
(acting through
significantly increased ADH-Vasopressin
release)
- Hypothesis
#NDC2.09
On one level, adaptation to ongoing
maximal leptin-enhanced lipolysis may
confer some degree of resistance to
ketosis
Hypothesis #NDC2.10
On another level, leptin may compete with
vasopressin to maintain mitochondrial
levels of OAA
|
"Vasopressin
increases cytosolic sodium concentration in hepatocytes
and activates calcium influx through cation-selective
channels.....";
"Ketogenesis in isolated rat-liver
mitochondria. IV. Oxaloacetate decarboxylation:
consequences for metabolic calculations.....";
"Type
I and II models of diabetes produce different
modifications of K+ currents in rat heart: role of
insulin.....";
"DKA
can occur in patients classified as Type 2 based on
previous insulin dose or subsequent oral Rx (Hispanics
were mainly type 2 (47%), with 34% type 1 and 19%
unknown. Whites were predominantly type 1 (80%), with 17%
type 2 and 3% unknown. African Americans showed a slight
preponderance of type 1 (53%), with a large number of
type 2 patients (44%) and 3% unknown).....";
Inositols and and Insulin
Resistance
"Insulin resistance, a result of reduced
synthesis of prostaglandylinositol cyclic phosphate, a
mediator of insulin action?
Regulation of cyclic PIP synthetase activity by oral
antidiabetic and antihypertensive drugs.....";
"Phosphoinositides
decrease ATP sensitivity of the cardiac ATP-sensitive
K(+) channel. A molecular probe for the mechanism of
atp-sensitive inhibition.....";
"D-chiro-inositol effective in reducing insulin
resistance................";
"Insulin resistant subjects lack islet adaptation to
short-term dexamethasone-induced reduction in insulin
sensitivity.................";
Genetic Markers of Insulin
Resistance
"Insulin resistance in Sicilians has
been linked to the PC-1 region of Chromosome 6 [but in
Mexican-Americans it has been variously linked to
Chromosomes 2,6,10,15,the SUR-1 receptor, and
TRP64ARG";
Inflammation, and Type 2
Diabetes....
"Higher BMI is associated with higher CRP
concentrations, even among young adults aged 17 to 39
years. These findings suggest a state of low-grade
systemic inflammation in overweight and obese persons......";
"Could Type 2 Diabetes be an inflammatory disease?
(Adipocyte IL-6 correlates with BMI, insulin
resistance,endothelial dysfunction, TNF-alpha, AND
CRP)..........";
"Leptin induces IL-1 which causes
fever and anorexia in rats.....";
"C-Reactive Protein is Strongly-Associated
With Measures of Obesity, Insulin Resistance, and
Subclinical Atherosclerosis in Healthy, Middle-Aged
Women...........";
Postprandial
Metabolism and Atherosclerosis Risk....
Plasma leptin concentration is a novel and
independent risk factor for CHD in WOSCOPS (Diabetologia [2001] 44 (Suppl
1): A315. EASD 37th Annual Meeting, #1209)
"Insulin treatment in type 2 diabetes
induces profound metabolic modifications of lipoprotein,
resulting in significant decrease of the intravascular
residence time of very low density lipoprotein,
intermediate density lipoprotein and low density
lipoprotein particles. This is likely to make these
particles less harmful. [Diabetologia (2000) 43: 27-35]....."
"In normal glucose tolerant offspring
of type 2 diabetics, PAI-1 activity was correlated with
plasma PAI-1 antigen level (r = 0.40, P =
0.02), fibrinogen (r = 0.45, P = 0.01), and
HDL cholesterol (r = 0.36, P = 0.04).
However, tPA antigen level, fasting and postload plasma
glucose and insulin, total cholesterol, triglycerides,
WHR, and BMI did NOT correlate
with PAI-1 activity.....";
"Perturbed handling of postprandial
triglycerides in normolipidemic CAD patients
involves the accumulation of apo C-Irich
large VLDL particles and the generation of small,
apo C-I and cholesterol-rich VLDL remnants.....";
"Fasting Insulinemia Appears to
Associate with Measures of BOTH Increased (t-PA antigen)
AND Decreased (PAI-1 antigen) Fibrinolytic Potential.....";
"Diabetic subjects have significantly (P<0.001)
more increased Dicarboxylic Acid (DA) excretion in urine
than corresponding healthy subjects. The yields of DA's
in each group decreased in the order
adipic>suberic>sebacic acid. Being stable and
easily detectable compounds, DA's may be considered
potential markers of oxidative attack on PUFA in diabetes.....";
"Data suggest that LDL particle size
should probably be added to the cluster of risk factors
that characterize the insulin resistance syndrome. The
association of 'insulin resistance' and LDL particle
diameter, however, is not mediated directly through the
level of insulinemia but via alterations in lipid
metabolism.....";
"The greatest cost savings in diabetes care is to be
had from reducing cardiovascular
complications............";
"The American Heart Association has conceded -
*Diabetes is now recognized as a major risk factor for
coronary heart disease*...........";
"Should we recognize another class of diabetes
called *Prandial Diabetes* with different risk factors?
Why? The new fasting ADA criteria seem to be less
predictive than the WHO criteria for the burden of
cardiovascular disease.........";
"A Common Mutation of the Insulin
Receptor Substrate-1 Gene Is A Risk Factor for Coronary
Artery Disease .....";
"Gender Difference in
Postprandial Lipemia:-Importance of Visceral Adipose Tissue
Accumulation.....";
"Postprandial hypertriglyceridemia - [NOT particle
size] - along with Proinsulin - [NOT insulin] - and
LDL-cholesterol -[NOT small-dense LDL] - found to
correlate with atherosclerosis.............";
"*Nonfasting* Serum Glucose and Insulin
Concentrations Significantly Increases the Risk of
Stroke..........";
"IGT correlates with increased CHD, CHD-related, AND
total mortality in
Japanese-Americans..............";
"Fiber
consumption predicts (fasting and postprandial)
insulin levels, weight gain, and other CVD risk factors
more strongly than total or saturated fat consumption.
.....";
"Even though *secondarily* associating with
increased cardiovascular disease in the elderly, higher
fasting plasma insulin appears to correlate with
*improved survival* in that population..........";
"Hypertension in Pima Diabetics Correlates with
Renal Disease and NOT with Cardiovascular
Disease............";
"HDL's from poorly controlled diabetics are abnormal
and do not inhibit LDL-oxidation or Apo-A1 fragmentation
in vitro............";
"NHLBI Investigators Identify HDL (*Good
Cholesterol*) Gene................";
"Proteinuria Is an Independent Risk Factor for
Ischemic Stroke in Non-Insulin-Dependent Diabetes
Mellitus.............";
"Homocysteine a significant risk factor for
atherosclerosis post-menopause..........";
"Silent Myocardial Ischemia with significant lesions
occurs in 20.9% of type 2 diabetic male patients who are
totally asymptomatic for CHD............";
"Effects of exercise on decreasing atherosclerosis
may be due to inhibition of cytokine
release................";
"Intensive Insulin Therapy Saves Lives in Acute MI's
(The DIGAMI Study)....................";
"Diabetes-Related Lower-Extremity Amputations
Disproportionately Affect Blacks and Mexican
Americans.............";
"*Legs for Life* offers free vascular screenings for
PVD (peripheral vascular disease) nationwide this
month..........";
High Carbohydrate Diets and
Atherosclerosis Risk....
"It seems appropriate to question the
wisdom of recommending that all Americans should replace
dietary saturated fat with CHO [AJC (2000)
85:45-48]....";
"Low-Cholesterol and High-Fat Diets
Reduce Atherosclerotic Lesion Development in
ApoE-Knockout Mice.....";"
"Protein-Rich Diets May Reduce Heart
Disease Risk............";
"The Western-Diet Results in
Insulin-Resistance, but not Atherosclerosis in
LDL-Receptor Deficient Mice with Hypercholesterolemia
(But high fructose diets do result in
increased atherosclerosis in the same model)...............
"Low Carb, High Fat Diet Appears to
Improve Major Risk Factors in Type 2 Diabetes.............";
"High-protein diets do increase
individual nephron filtration rate (INFR) and affect
glomeruli adversely (1) directly with individual nephron
filtration rate increase and (2) inversely with total
glomerular filtration rate (GFR) diminution (thus the
effect is small in normal functioning kidneys and large
in renal impairment).....";
"Western-Diet (high in meats and
fats) protective against stroke dementia: Honolulu-Asia
Aging Study.....";
Therapeutic Interventions into
Diabetic Atherosclerosis....
"Marine omega-3 fatty acids improve
large artery endothelium-dependent dilation in subjects
with hypercholesterolemia without affecting
endothelium-independent dilation (JACC 35:265-270,
2000)....."
"PPAR-gamma activators inhibit
expression of VCAM-1 and ICAM-1 in activated
endothelial cells and significantly reduce
monocyte/macrophage homing to atherosclerotic plaques.
These findings suggest that PPAR-gamma activators,
currently used in treatment of type 2
diabetes, may have beneficial effects in
modulating inflammatory responses in atherosclerosis.....";
"Results extend previous findings in
patients with DM to a larger cohort, confirming the
benefit of cholesterol lowering with simvastatin
treatment on CHD events. In addition, significant
decreases in total mortality, major coronary events, and
revascularizations were observed in simvastatin-treated
patients with impaired fasting glucose levels. These
results strongly support the concept that cholesterol
lowering with simvastatin therapy improves the prognosis
of patients with elevated fasting glucose levels (above
6.0 mmol/L [above 110 mg/dL]) or DM and known CHD......";
"Lipid-lowering therapy generally
should be more aggressively applied to patients with
diabetes and/or at the time of coronary heart disease
(CHD) diagnosis.....";
"Eicosapentaenoic Acid and Docosahexaenoic
Acid Block Serotonin-Induced Smooth Muscle Cell
Proliferation........."
"Fish
Oils Safe and Effective in Angiographic
Placebo-Controlled Trials of Coronary Artery Regression and in MI
Survival "
"Alcohol use inversely associated with coronary
mortality in older onset diabetics............";
"Nitrendipine Improves Diabetic Mortality in the
Elderly with Systolic Hypertension..............";
"Gemfibrozil lowers CHD events but again fails to
affect total mortality [this time in CHD patients with
low HDL and even despite an expected high total mortality
from CHD in this population....... ";
"ADA recommends treatment of all diabetics as though
they have coronary disease by NCEP II
guidelines........";
"Aggressive Cholesterol Lowering after CABG Shows
Angiographic Benefit but FAILS to show a Significant
Clinical Benefit in Diabetics...........";
"Reo-Pro and half-dose TPA are as effective as
angioplasties in acute myocardial
infarctions..............";
"EAS Study rates Lipitor More Effective Than Zocor
or Baycol in reaching target goals............";
"Stents help diabetic patients who require coronary
revascularization..........";
"Use of Reo-Pro with Stents Improves Diabetic
Survival..............";
"Treatment with ramipril, an ACE inhibitor, can
significantly reduce the risk of heart attack, stroke,
cardiovascular death and kidney disease in high-risk
people with diabetes...........";
"An isoflavone dietary supplement, P-081, derived
from red clover, significantly increases HDL cholesterol
levels in postmenopausal women not taking estrogen
Rx.........";
"Compared with placebo, long-term use of cilostazol,
100 mg or 50 mg, twice a day significantly improves
walking distances in patients with intermittent
claudication........";
Therapy of Type 2 Diabetes....
"Hepatocyte Growth Factor Overexpression
in the Islet of Transgenic Mice Increases Beta Cell
Proliferation, Enhances Islet Mass, and Induces Mild
Hypoglycemia.....";
Guava fruit may benefit
type 2 diabetics.....";
"Long-Acting GLP-I agonist
Exendin-4 Stimulates Both beta-Cell Replication and
Neogenesis, Resulting in Increased beta-Cell Mass and
Improved Glucose Tolerance in Diabetic Rats....."
Glucagon-Like Peptide 1 and
Exendin-4 Convert Pancreatic AR42J Cells Into Glucagon-
and Insulin-Producing Cells .....";
NDC recommends metformin as first line MONOTHERAPY
therapy in the OBESE (BMI>30) type 2 patient but also
recommends caution when using metformin combination with
sulfonylurea agents.......";
"ISRAELI
STUDY IS NOW THE FOURTH (!) TO SHOW INCREASED MORTALITY
WITH METFORMIN- SULFONYLUREA COMBINATION THERAPY..........";
"Bristol-Myers Squibb warned about Glucophage
adverse event reporting.............";
"FDA foolishly rejects important new
antibiotic................";
"GLP-1 is able to normalize plasma glucose
in all type 2-diabetic patients studied. This analysis
underlines the great therapeutic potential of GLP-1.....";
"Actos (pioglitazone) approval in Type 2s as
monotherapy or in combination with metformin, insulin, or
SFU's cautioned by edema, weight gain, and anemia but
heartened by lowering
triglycerides.................";
"Avandia (Rosiglitazone) approval by FDA cautioned
by LDL increase, edema, anemia, and
weight-gain.............";
"The allele frequency of the PPAR gamma 2 missense
mutation Pro12Ala variant is 0.12 in Caucasian Americans,
0.10 in Mexican Americans, 0.08 in Samoans, 0.03 in
African Americans, 0.02 in Nauruans............;
"D-chiro-inositol effective in reducing insulin
resistance................";
"Beta Cell Failure Gets Almost All Type 2 Diabetics
In Time.............";
"Type 2 diabetics will eventually require insulin
for good control.........";
Etiology of Type 1 Diabetes...and
the IL-4 Pathway....
"Natural Killer (NK) Cells
Associate with Destructive Autoimmunity in Type 1 Models
(Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0402065101)"
"IL-12 locally produced by
islet-infiltrating cells plays a critical role in the
development of type 1 diabetes" (J
Autoimmunity [2001]16:97-104)
"hCMV may be involved in the
loss of T cell tolerance to autoantigen GAD65
by a mechanism of molecular mimicry leading to
autoimmunity.Proc. Natl.
Acad. Sci. USA, [2001] 98, Issue 7, 3988-3991"
"pDNA vaccination is an
effective strategy to prevent IDDM - IL-4 was also
required for
disease prevention
(The Journal of
Immunology[2001] 166: 2122-2132)"
"Some patients with idiopathic type 1
diabetes have a nonautoimmune, fulminant disorder
characterized by the absence of insulitis and of
diabetes-related antibodies, a remarkably abrupt onset,
and high serum pancreatic enzyme concentrations. (N Engl
J Med 2000;342:301-7.).....";
"Blocking interaction
between CD44, hyaluronic acid prevents type 1 diabetes in
NOD mice.....";
"Genetic Abnormality in
Diabetic Mice May Answer Why Autoimmune Disease Are More
Common in Women .....";
"The Human ENSA Gene That Encodes alpha-Endosulfine,
a Regulator of beta-Cell KATP Channels, has been
localized to an area of Chromosome 14 with IDDM
susceptibility-linkage (IDDM11)..............";
"An insulin peptide fragment has been identified as
an autoantigen in the NOD [Non-Obese Diabetic] mouse
model..........";
"Focus of attack in Type 1 diabetes may be
*stiff-man* antigen GAD.........";
"In
identical twins discordant for type 1 diabetes the diabetic siblings appeared
to secrete NO
interleukin-4.......";
"IL-13 reduces incidence of Type 1
diabetes in NOD mice...........";
"Interleukin-4 appears to prevent insulitis and the development of Type 1 diabetes in the NOD mouse model.....";
Therapy of Type 1 Diabetes....
"Still More Participants
Needed for Natiowide Study to Prevent Type 1 Diabetes.....(call
1-800-425-8361)";
"Long-Acting GLP-I agonist
Exendin-4 Stimulates Both beta-Cell Replication and
Neogenesis, Resulting in Increased beta-Cell Mass and
Improved Glucose Tolerance in Diabetic Rats....."
Glucagon-Like Peptide 1 and
Exendin-4 Convert Pancreatic AR42J Cells Into Glucagon-
and Insulin-Producing Cells .....";
"The Insulin Gene has successfully been transfected
into diabetic rat livers and significantly improves
glycemia..............";
"MCV group is now the second to have
transfected the insulin gene into hepatocytes.....";
"Ultralong-acting Insulin (Glargine) Safer but as
Effective as NPH in Types 1 and 2
diabetics........";
"Basal-Bolus (Ultralente/Regular) Insulin Regimen
Highly Effective with Carbohydrate Counting in Type 1
Diabetes............";
"Orally administered amidated pectin insulin (PI)
hydrogel beads sustain plasma concentrations of insulin
in streptozotocin (STZ) diabetic
rats..............";
"Oral insulinomimetic found in the African
rainforests (shades of *The Medicine Man* - eh?)..........";
Diabetic Monitoring and
Microvascular Complications (and Atherosclerosis?....)
"Coronary Disease in
Type 1's Correlates with Depression, NOT Glucose. Lower
Extremity Arterial Disease, however, DOES Correlate with
Blood Glucose in Type 1's.....";
"Presence
of more severe retinopathy or visual impairment in
diabetic patients is a risk indicator for increased risk
of ischemic heart disease death. Presence of these ocular
conditions may identify individuals who should be under
care for cardiovascular disease......";
"Children and young adults with insulin
dependent diabetes continue to be at increased risk for
death from diabetic ketoacidosis.....";
"Early renal function decline is 3 times more likely
to develop in blacks than whites and potentially
modifiable factors,
including lower socioeconomic status, suboptimal health
behaviors, and suboptimal control of glucose
levels.............";
"Inhibitor of Diabetic Proliferative Retinopathy
Unmasked............";
"Watch Sensor Apparently Effective in Monitoring
Blood Sugars Non-Invasively Recommended for
Approval..........";
"Data suggest that persons with type 1 diabetes may
not judge correctly when their BG level is too low to
permit safe driving
and may consider driving with a low BG level even when
they are aware of the low level.
Health care professionals should counsel their patients
about the risk of driving with hypoglycemia
and the importance of measuring BG level before
driving.............";
"Conservative Therapy WITHOUT AMPUTATION Safe and
Effective for Diabetic Foot Ulcers and
Osteomyelitis.............";
"Foot Surgery in Diabetes Leads to Increased
Degenerative Changes.........";
"Gabapentin not superior to amitriptylline in small,
under-powered, cross-over study of pain relief in 28
diabetic neuropathic patients.............";
"Diabetes common (3x-increased) in hospitalized
bipolar patients............";
"Parent-Teen Integration into the Diabetic Team
Affects Outcomes Positively...........";
Home
Page
Reload The National Diabetes
Center Site
|