THE Diabetes DAILYNEWS CONCEPTUAL INDEX
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Postprandial Metabolism and Atherosclerosis Risk....

"In multivariate Cox models, the age-adjusted hazard ratio for insulin resistance factor during the 22-year follow-up was 1.28 (95% CI 1.10 to 1.50) with regard to CHD risk and 1.64 (95% CI 1.29 to 2.08) with regard to stroke risk. Lipid factor predicted the risk of CHD but not that of stroke, and lifestyle factor predicted a reduced CHD risk. Factor analysis including only 6 risk factor variables proposed to be central components of insulin resistance syndrome (body mass index, subscapular skinfold, AUC insulin, AUC glucose, mean blood pressure, and triglycerides) produced only a single insulin resistance factor that predicted the risk of CHD and stroke independently of other risk factors....(Arteriosclerosis,Thrombosis and Vascular Biology[2000]20:538)"

"Decreased post-heparin lipase activity may have a role in the increased risk of CAD among patients with NIDDM." Atherosclerosis [1994] 105(1):25-34

"Insulin treatment in type 2 diabetes induces profound metabolic modifications of lipoprotein, resulting in significant decrease of the intravascular residence time of very low density lipoprotein, intermediate density lipoprotein and low density lipoprotein particles. This is likely to make these particles less harmful. [Diabetologia (2000) 43: 27-35]....."

"In normal glucose tolerant offspring of type 2 diabetics, PAI-1 activity was correlated with plasma PAI-1 antigen level (r = 0.40, P = 0.02), fibrinogen (r = 0.45, P = 0.01), and HDL cholesterol (r = –0.36, P = 0.04). However, tPA antigen level, fasting and postload plasma glucose and insulin, total cholesterol, triglycerides, WHR, and BMI did NOT correlate with PAI-1 activity.....";

"Perturbed handling of postprandial triglycerides in normolipidemic CAD patients involves the accumulation of apo C-I–rich large VLDL particles and the generation of small, apo C-I– and cholesterol-rich VLDL remnants.....";

"Fasting Insulinemia Appears to Associate with Measures of BOTH Increased (t-PA antigen) AND Decreased (PAI-1 antigen) Fibrinolytic Potential.....";

"Diabetic subjects have significantly (P<0.001) more increased Dicarboxylic Acid (DA) excretion in urine than corresponding healthy subjects. The yields of DA's in each group decreased in the order adipic>suberic>sebacic acid. Being stable and easily detectable compounds, DA's may be considered potential markers of oxidative attack on PUFA in diabetes.....";

"Data suggest that LDL particle size should probably be added to the cluster of risk factors that characterize the insulin resistance syndrome. The association of 'insulin resistance' and LDL particle diameter, however, is not mediated directly through the level of insulinemia but via alterations in lipid metabolism.....";

"The greatest cost savings in diabetes care is to be had from reducing cardiovascular complications............";

"The American Heart Association has conceded - *Diabetes is now recognized as a major risk factor for coronary heart disease*...........";

"Should we recognize another class of diabetes called *Prandial Diabetes* with different risk factors? Why? The new fasting ADA criteria seem to be less predictive than the WHO criteria for the burden of cardiovascular disease.........";

"A Common Mutation of the Insulin Receptor Substrate-1 Gene Is A Risk Factor for Coronary Artery Disease .....";

"Gender Difference in Postprandial Lipemia:-Importance of Visceral Adipose Tissue Accumulation.....";

"Postprandial hypertriglyceridemia - [NOT particle size] - along with Proinsulin - [NOT insulin] - and LDL-cholesterol -[NOT small-dense LDL] - found to correlate with atherosclerosis.............";

"*Nonfasting* Serum Glucose and Insulin Concentrations Significantly Increases the Risk of Stroke..........";

"IGT correlates with increased CHD, CHD-related, AND total mortality in Japanese-Americans..............";

"Fiber consumption predicts (fasting and postprandial) insulin levels, weight gain, and other CVD risk factors more strongly than total or saturated fat consumption. .....";

"Even though *secondarily* associating with increased cardiovascular disease in the elderly, higher fasting plasma insulin appears to correlate with *improved survival* in that population..........";

"Hypertension in Pima Diabetics Correlates with Renal Disease and NOT with Cardiovascular Disease............";

"HDL's from poorly controlled diabetics are abnormal and do not inhibit LDL-oxidation or Apo-A1 fragmentation in vitro............";

"NHLBI Investigators Identify HDL (*Good Cholesterol*) Gene................";

"Proteinuria Is an Independent Risk Factor for Ischemic Stroke in Non-Insulin-Dependent Diabetes Mellitus.............";

"Homocysteine a significant risk factor for atherosclerosis post-menopause..........";

"Silent Myocardial Ischemia with significant lesions occurs in 20.9% of type 2 diabetic male patients who are totally asymptomatic for CHD............";

"Effects of exercise on decreasing atherosclerosis may be due to inhibition of cytokine release................";

"Intensive Insulin Therapy Saves Lives in Acute MI's (The DIGAMI Study)....................";

"Diabetes-Related Lower-Extremity Amputations Disproportionately Affect Blacks and Mexican Americans.............";
"*Legs for Life* offers free vascular screenings for PVD (peripheral vascular disease) nationwide this month..........";


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