THE Diabetes DAILYNEWS CONCEPTUAL INDEX
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Therapeutic Interventions into Diabetic Atherosclerosis....

"Insulin therapy improves endothelium-dependent and -independent vasodilatation. These data support the idea that insulin therapy has beneficial rather than harmful effects on vascular function...."(Arteriosclerosis,Thrombosis and Vascular Biology[2000]20:545)

"Marine omega-3 fatty acids improve large artery endothelium-dependent dilation in subjects with hypercholesterolemia without affecting endothelium-independent dilation (JACC 35:265-270, 2000)....."

"PPAR-gamma activators inhibit expression of VCAM-1 and ICAM-1 in activated endothelial cells and significantly reduce monocyte/macrophage homing to atherosclerotic plaques. These findings suggest that PPAR-gamma activators, currently used in treatment of type 2 diabetes, may have beneficial effects in modulating inflammatory responses in atherosclerosis.....";

"Results extend previous findings in patients with DM to a larger cohort, confirming the benefit of cholesterol lowering with simvastatin treatment on CHD events. In addition, significant decreases in total mortality, major coronary events, and revascularizations were observed in simvastatin-treated patients with impaired fasting glucose levels. These results strongly support the concept that cholesterol lowering with simvastatin therapy improves the prognosis of patients with elevated fasting glucose levels (above 6.0 mmol/L [above 110 mg/dL]) or DM and known CHD......";

"Lipid-lowering therapy generally should be more aggressively applied to patients with diabetes and/or at the time of coronary heart disease (CHD) diagnosis.....";

"Eicosapentaenoic Acid and Docosahexaenoic Acid Block Serotonin-Induced Smooth Muscle Cell Proliferation........."

"Fish Oils Safe and Effective in Angiographic Placebo-Controlled Trials of Coronary Artery Regression and in MI Survival "

"Alcohol use inversely associated with coronary mortality in older onset diabetics............";

"Nitrendipine Improves Diabetic Mortality in the Elderly with Systolic Hypertension..............";

"Gemfibrozil lowers CHD events but again fails to affect total mortality [this time in CHD patients with low HDL and even despite an expected high total mortality from CHD in this population....... ";

"ADA recommends treatment of all diabetics as though they have coronary disease by NCEP II guidelines........";

"Aggressive Cholesterol Lowering after CABG Shows Angiographic Benefit but FAILS to show a Significant Clinical Benefit in Diabetics...........";

"Reo-Pro and half-dose TPA are as effective as angioplasties in acute myocardial infarctions..............";

"EAS Study rates Lipitor More Effective Than Zocor or Baycol in reaching target goals............";

"Stents help diabetic patients who require coronary revascularization..........";

"Use of Reo-Pro with Stents Improves Diabetic Survival..............";

"Treatment with ramipril, an ACE inhibitor, can significantly reduce the risk of heart attack, stroke, cardiovascular death and kidney disease in high-risk people with diabetes...........";

"An isoflavone dietary supplement, P-081, derived from red clover, significantly increases HDL cholesterol levels in postmenopausal women not taking estrogen Rx.........";

"Compared with placebo, long-term use of cilostazol, 100 mg or 50 mg, twice a day significantly improves walking distances in patients with intermittent claudication........";


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